Zendesk ticket was raised and accepted as a bug as follows:
Request #105223 CTD at specific location coordinates - NINUK - 30°52’37.0"N 072°49’34.0"E
Support Tuesday at 20:05
Hi Khurram,
Thanks for bringing this matter to our attention.
This issue has been tracked in our internal bug tracker. Our QA team will review the information and try to reproduce the issue. Bugs and issues that have been successfully reproduced will be categorized and prioritized—game-breaking bugs will receive the highest priority, while middle-of-the-road and cosmetic bugs are prioritized based on reproduction and the number of times reported.
We’ll come back to you if we need more information or if we have troubleshooting steps to recommend.
Kind regards,
Microsoft Flight Simulator Support Team
Can refer to this thread for other related discussion. Try for yourselves - try to launch a flight from OPRQ and should CTD.