Hello,
I’ve found the problem for my system, I have been getting long freezing during mif flight, like around 1 minute or so. And then I’ve realized that when I unplugged any HW, MSFS is always freezing for long time. And then I figured out that my mouse which is wireless Logitech is shutting itself off if I don’t touch it for a while and this is causing the freezing on MSFS, similar to unplugging any other HW. It also freezes again when I touched the mouse because this time it is detecting the plugging HW. If you are having similar problems then you can switch to any basic mouse/keyboard with wire or you can disable the stand by function for battery saving for your HW.
Hope this helps to you too.