5hrs into a TBM930 flight, cockpit unresponsive to mouse clicks

The unresponsive cockpit issue, not the freeze, can be resolved by opening one of the docked windows from the top menu, such as the VFR map, or ATC. Click on that windows title, then close it again, and the cockpit will become responsive again.

Since the OPs system froze later, it may not be this, but it sure sounds like it.