Are others also still having issues with Saitek Multi Panel not working properly when starting cold & dark?

Do you have the plugin for MSFS installed?
If not, get it here:
https://download01.logi.com/web/ftp/pub/techsupport/simulation/MSFS_Plugin_x64_Software_8.0.313.0.exe

However, sometimes MSFS gets confused after restarting the game and the plugin won’t work. Then simply open the task manager, stop the plugin and restart it.