No, never had an issue. Its a pretty standart USB Hub. (A powered one and I think thats important).
I use my desk for normal computer stuff so whenever I want to fly I need to set up my peripherals. So I plug in my two Virpil Control Panels, two Logitech panels, Velocity One yoke and the Honeycomb Bravo… oh yeah, and a keypad for komms.
No problems.
If you have more questions, just shout !