I have the same kind of issue since the latest World update 4.
The sim crasht, however this was after adding fuel the to center tank because of lack of fuel for the long haul trip from Schiphol to Willemstad with the 748.
After adding the fuel everything was fine, but as soon as I touched the FMC the sim crasht to the desktop.
System:
Nvidia 3080
AMD 3700
during VR → Quest 2