Can It Be Assumed That Items Purchased From In-Sim Marketplace Will Not Cause CTD's?

No, but the majority of CTDs will be caused by items which are not in the marketplace.

But sorry I have to ask you if you own MSFS? or are you scared by the horror stories that it will CTD all the time. Because in that case let me tell you that not all of us have an unusual amount of CTDs. I had 2 in all of September and during the same time X-Plane had at least 3 times more.

i.e. all sims will sometimes CTD if you put in big mods, risk running out of memory or alt-tab to name a few things.

The thing with MSFS is that by nature it has a very high data transfer rate, that means if you have any kind of issue with eg memory, harddisk or internet transfer it will reveal those issues. You may get away with games that only use tiny amounts of memory and then MSFS appears to be faulty when in fact it is your computer.