Can’t Save a flight in VR?

Known issue (happened to me).

MSFS likes being in Full Screen mode, in VR though Full Screen will stay on top of any explorer pop-up windows and you cannot Alt-Tab properly.

Remedy is, first ALT-ENTER to go from MSFS Full Screen mode to Windowed mode, then Load/Save, or now you can Alt-Tab to the explorer window, and vice versa back.

MSFS always saves the state of the screen on the time of quitting.