Can't change aircraft, can't select departure, FLY NOW is greyed out

Just me or is this the latest update effect?

Ditto here. Same symptoms; program was rendered unusable by the update.

Do a full shut down of your PC. Start it up and open Flight Sim 2020. That should start another download around 4 GB in size. After that, it should work. That is what worked for me. I tried closing the sim prior to that and restarting it and nothing changed. The full shut down did the trick for me.

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