I seem to have some success:
First I “Reset&Repair” the game in the XBox app. This seemed to have resolved the click spot issue.
However, now I encountered some new problem: None of my sidestick / yoke (TCA and Honeycomb Alpha) aileron and elevator controls worked. They all worked in the controls section of MSFS2020, but not in any of my aircraft (Fenix, FBW and PMDG).
So I read somewhere, a guy recommended to RESET the USB controller in your PC, by unplugging all connected USB devices and rebooting the PC.
After I did this the controls seem to behave normal again. I performed a flight from EDDF to LOWI and all went smooth.
I hope this took care of my issues
I will report back if new problems arise.