I’m noticing pretty severe pixelization in the towering clouds after the latest patch too (1.10.8.0). My graphics card is a GeForce RTX 2070 SUPER with the latest 457.09 drivers and all FS2020 sliders set to Ultra.
I have tried modding the UserCfg.opt to remove all post processing as suggested, as well as forcing my Anti Aliasing - Transparency to 8x supersample in the nVida control panel but no luck. Stratus clouds and lower cumulus clouds don’t have any issues- it just seems to be the towering large volume types.