Hi @coxo2436,
Are you having to do this because the bindings are getting wiped out? Or a feature suggestion of having different bindings for each aircraft?
There is a wishlist for this feature:
Ability to have separate control setups for each plane without having to manually switch between 20+ controller profiles? - Self-Service / Wishlist - Microsoft Flight Simulator Forums
If this is a bug, where bindings are getting wiped out, please also submit that to zendesk.