Welcome to the club. If you’re using AMD one thing to check is Event Viewer → Windows Logs → System for any driver errors similar to “Display driver amdkmdag stopped responding and has successfully recovered”, a few seconds before the d3d11.dll message you are seeing.
I don’t really think VC++ libraries play any role in this as MSFS seems to be using its own (I know because I had 1.25.x installed while the Vcruntime140.dll error was for version 1.28). At this point I must have tried a million workarounds (Windows reinstall included) but the game always crashes after the loading screens with either of these DLL errors, probably due to a driver timeout.
Currently I’m running a Linkpack Extreme test on my 2x16GB RAM modules to verify if XMP2.0 is stable (which shouldn’t matter as MSFS also crashes with XMP off or with XMP underclocked). GPU stress tests were successful, other games are performing fine and there are no random crashes anywhere else except with MSFS (which aren’t really random as it effectively crashes at the exact same place all the time).
The only “workaround” I’ve found is to delete random files from “C:\Users{USERNAME}\AppData\Local\Packages\Microsoft.FlightSimulator_8wekyb3d8bbwe\LocalCache\Packages” so that MSFS will redownload them again. Usually when this happens it’ll let me stay in the main menu for 10-20 minutes before it crashes again for no apparent reason. Next time I launch it it’s a 100% crash after the loading screens.
Up until a few days ago I could run the game with AMD Tuning set to manual by only setting a random max fan speed value and/or a power limit. After some point (I think after AMD latest drivers 21.3) this was no longer working but I’m not sure it’s a drivers thing because ever since I’ve done a Windows reinstall and have tried all AMD versions between now and November. None has worked even after clean DDU reinstalls, even without Adrenaline package but just the driver.
You may try the various crazy workarounds proposed in different discussions but unless Asobo release a proper anti-CTD fix I very much doubt we’ll see an end to these issues.