For your information I’m now running windows 10 up to date. Flight simulator version: 1.30.12.0
and Nvidia version: 516.49.
Yes I cleaned everything and started on a fresh disk, then I updated my windows, and right after that and before even installing anything I installed FS and it works right away.
Based on the number of reported CTDs, it seems likely that the issue is related to the system but for those already using windows 10, the only solution I can suggest is to find what is wrong with their system, and If possible, starting with a fresh installation of windows may be helpful in resolving the issue.