For anyone that wants a fix, go to your install folder (if you got it from the MS store. Sorry if you didn’t no idea)
You’re looking for a folder somewhere like: C:\Users\AppData\Local\Packages\Microsoft.FlightSimulator_8wekyb3d8bbwe\SystemAppData\wgs\
Go in there, open each file denoted with type of “File” in something like Notepad+ or Sublime text.
If it’s for a peripheral that’s not a keyboard/mouse, back it up somewhere else and delete the sub-folder it was in (if you get one that’s a bunch of blocks of numbers, leave that).
This seems to have fixed it for me. You get to rebind your peripherals buttons, but it at least doesn’t seem to CTD anymore.
EDIT: Opus explains it better here: CTD after latest update (Update #5)