CTD on Sim Start

to be sure … I assume its a new install, without installed Mods… you was never able to start the game ?

At first would be good that you post the message from windows event log, with bit luck we get an idea.

Some users also helped to start the application with -FastLauch… others, in case of gpu issues, with limiting the fps in nvidia control panel. But sometime is also simple the EN Lang Pack not installed.
Here’s also a FAQ ('s) with steps you can try: https://flightsimulator.zendesk.com/hc/en-us/articles/360015893879-All-versions-Crashing-CTDs-issues-Checklist