i think i have a Solution. In the last time i had no issues, but after change the ram (from 3000mhz to 3600mhz) i’m getting CTDs, also with Vanilla-FS.
After reducing the Ram-frequency to 3400mhz the CTDs are gone
Ryzen 5900X
RX 6900XT
Corsair Vengeance LPX 32gb 3600mhz (reduced in UEFI to 3400mhz)
ASUS B550 Gaming F WIFI
FS installed on Samsung 970 EVO NVME
SAM acctivaed