Boudewijn,
I would not try it because chances of a good outcome are very limited. Even the install would be painfull. In my own test 50 mbs is really needed (but it should run fine with that). See the very good data from Toms Hardware here: Microsoft Flight Simulator 2024 PC performance testing and settings analysis — we tested 23 GPUs, the game is even more demanding than its predecessor | Tom's Hardware
Consider Xplane, that can run fully local.