Does anyone have an issue where the entire screen goes black for a few seconds every now and then?

Also, here are my current driver settings in case you notice anything strange. I’ll probably wait until the weekend to try a clean installation since I’ll need some time to figure that out (thank you for the directions!)

Those settings look fine. Just make sure that during the clean installation you don’t install the NVIDIA App.

How old is the monitor? What happens if you disable HDR in Windows?