Dual GPU - Geforce 3080 for Rendering & Radeon 570 for Other Monitors

In my limited testing there is no help using a second card for the pop out windows. (nVidia 1070/960)

Your primary card is still doing all the work, the secondary card is just showing it to you.

If the pop outs were seen as a second app and could be directed to be rendered by the second card it would work.