I had this three times this morning while just sitting at the gate in the Fenix A320. I did update my Nvidia drivers last Friday but tested with 3 flights all around 2 - 3 hours in length and had zero issues. I have never had this CTD before. I did try the regedit fix and on the 4th time did not have the error. Now 1.5 hours into the flight and all good so far.
Could this be a MSFS 2020 issue rather than a GPU issue?
UPDATE
I did manage to complete the flight after making the change in the registry but now I get the same CTD a few minutes after loading into the sim at the gate. Man this is really frustrating. I have no overclock on my 4090 (Never have)
I think I will try going back to 566.03 instead of 566.14
If anyone has any other ideas I will be glad to hear them