I can’t see any way that the NXi could affect the CRJ. The CRJ is written in C++, running under WASM, while the NXi is JavaScript/HTML. (It might use some WASM behind the scenes, but that would only be active when an NXi-equipped aircraft is loaded).
I fly the CRJ almost exclusively, and have had the NXi installed since the first beta version came out, and have never had any problems.