Just performed a quick test with OpenXR Preview runtime (109.2111.23003) as suggested and I’m more than happy to say I wasn’t able to force a CTD even after switching between 2D-VR-2D probably 10-15 times in a row.
Will need to do more testing when doing this also when flying. Now I just sat on the apron in a cold & dark TBM 930. If this works equally good during flight, this is a historic day I would say after having this issue since MSFS was first released.