Similar to what FrankPilot1530 has said.
Prepare a flight plan with waypoints, use slow Icon A5 so you have a good and stutter free PC performance.
Also, clear weather, daytime, use autopilot, do a dry run, look at free add on scenery for the areas on your flight plan, use something like LittleNavMap so that you can give a running commentary on the places you are currently flying over (population, major points of interest etc), decent speakers, background music (??), plenty of tea and biscuits!
Have a great time.
