GPU usage and FPS plummeted 2.5 hours into flight

It’s not only you. I have the same issue and if you look into the forums over at avsim.com there are plenty of people suffering from it.
I never had any performance issues with MSFS but yesterday i had to quit the sim shortly before landing due to FPS drops down to 10. Was about a 2 hour flight.
I usually do multi hour flights up to 7 or 8 hrs and never had any issues.