I have the three main screens on the DP sockets of the 3080ti, then I enabled the on-board graphics for the mobo (ROG STRIX Z690-A GAMING WIFI D4) which offered me a DP socket and an HDMI socket so they run the two touch panels at 60Hz 1080p, not shown but i later added a 6th monitor - an old PC display I think at something like 1200x900 running off the HDMI socket on the 3080ti - this only runs my Volanta log book and maybe a chart or two if needed.
Its pretty much flat-out and CPU bound a fair bit but the GPU is balanced to give almost equal load to CPU & GPU now by tweaking the TLOD & OLOD values and othe graphics settings where needed. I’m getting 30 to 45 FPS for most scenes.