My experience comes from 3 years using VR in X-Plane and streaming the same on Twitch for over a year.
When I use VR I also have my yoke mounted to my desk and pedals are under it in the same place as it would be in a real plane. I have my VR environment adjusted so the virtual instrument panel is in front of my desk so I do not hit anything when I am flipping switches, adjusting the throttle and adjusting trim or flaps.
I just got done with a stream flying over the UK doing the same route that I have done in MSFS. The last time I used the mouse was to enable VR in X-Plane and the next time was to stop the stream all the rest was done with my Valve Index controllers with my HP Reverb G2.
If you want you can look at my stream on Twitch or YouTube to see how I interact with the VR cockpit and sure hope I can have that same experience here in MSFS. My only ask is to give me the choice so we can all have what we enjoy most.
Thanks for reading Bill