Do you have the same issue if you follow the OP’s steps to reproduce it?
No
Provide extra information to complete the original description of the issue:
Could you try creating a new, default, profile for that controller, and see if changing the bindings in that profile has the issue? Don’t clone the existing one as you might bring across the problem to the clone, but create a new empty one.
If relevant, provide additional screenshots/video:
If on PC, Fault Bucket ID - Instructions here - Please type in just the Fault Bucket ID # rather than a screenshot for privacy reasons: