This is going to be lengthy but hopefully helpful.
Things to check:
(System)
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What performance mode is windows set to (recommend performance or ultra)
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HAGS (i am now reading people benefiting from having it set to on, so try both settings with a reboot after setting then test)
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Ram speed (in bios is it set to xmp profile? Recommend xmp if possible)
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Virtualization (bios) recommend OFF
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Once sim is running Open task manager and select the flightsimulator.exe right click and select Go To Details. Right click the .exe again go to Set CPU Priority and select High. If you see improvement with this setting and want it to always load with High for its cpu priority setting, you can download and install an app call Prio process priority control. Once you have that installed, then reboot pc, run msfs again then open Task Manager again following the steps above to set the CPU priority to high. That’s all. From now on prio will automatically set the exe to run in high priority.
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With Task Manager open go to Startup tab and disable any and all programs (non essential) to your system) for instance i have everything disabled except my rgb lighting software, external soundcard driver, voicemeeter and Nexus app.
(GPU settings)
Recommend following this guide specifically the power setting.
Finally I’d recommend looking at the temps. Take off side panel and see if performance becomes more stable. I have an open air case with multiple added fans…fans blowing on chipset, ram, north & south bridge…heat is the “enemy” so i say minimize it wherever possible. No need to add fans…but consider opening the side panel while simming…i definitely notice more heat generation when playing msfs then with most other titles i play so i can imagine the heat in a closed case system gets up there.
Hopefully these suggestions will net you a performance/stability gain.