I’ve been having this problem since MSFS came out. Every single flight i get a random freeze, all my hardware controls reset to a default state until I move a lever on my Bravo a little bit. On some planes i.e the Quest Kodiak, I lose ignition after this happens. I’ve disabled all USB Selective Suspension settings, haven’t been able to figure it out.
I also have a Logitech x52 which does not produce the same result.