If you are doing an IFR flight plan, you should be given an arrival runway and approach by ATC when you are 50-60 miles out. You can then confirm the approach and runway or ask for a different one through the ATC menu.
Just like the departure runway, you will generally be landing into the wind.
I would highly recommend you looking at approach plates and airport diagrams. That will help you a lot and make a lot more sense once you can visually see what ATC is asking you to do. You can find most airport diagrams by just typing “KJFK airport diagram” or " EGLL airport diagram" into google. I like to use Navigraph.