Find an aviation weather source on the web and use the wind to determine which RW would be best. There are exceptions, but typically you’d like you land in as close to a headwind as possible. But sometimes it’s not possible and you just have to do your best. If you’re flying into larger US airports, you can find the real world ATIS here that will tell you which runway they’re using, in addition to some other info about approaches in use.
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