Yep. Overclocked CPUs are definitely tipped over the edge by MSFS. I’ve also found that the sim is much more stable if I actually underclock my memory ie I’ve got my 3200Mhz Corsair Vengeance LPX running at 3133Mhz.
Edit: just noticed you were referring to GPU. Overclocked GPU is fine for me (2070 windforce)