Hello,
this isn’t easy, this depends simply to existing ATC services, terrain around departure airport and also regional rules. In sim? Not possible probably via in sim ATC as not functional as expected. In case of your only flight in sim (you’re curious how to do that), I can recommend start via VFR, do under VFR conditions reach of expected first IFR route waypoint and change to IFR, simply safety first. Under IFR and restrictions with specific IFR routes, you can be in safe. In real world and with airliners is simply expected that ATC services with radar are existed, so radar departures services can be provide to you.
On other side, there are many similar Topics already where all PROs like Rico??? or Snail and other PROs can give you recommendations, answers to your specific question, no doubts.