Couple of things might be going on here.
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You could be running out of RAM.
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Could be a very unique glitch in the sim.
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Have you checked your temperatures? Might be an overheating problem.
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Make sure Windows is up-to-date.
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Maybe you should consider an upgrade to Windows 11.
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Something in the flight Sim could be corrupt maybe doing a fresh install might help.
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If all else fails, and you can’t get it to run without crashing, I would reinstall Windows.
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I’m not sure what you have in your community folder, but maybe consider deleting everything out of it, and trying the flight again.
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Try to reset and repair the Microsoft flight Sim app from the application settings menu.
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Remove any over clocks, that you might have running.
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I’m not sure what kind of power supply you’re running but if it’s anything less than 850watt you could be power starving you’re 4090 GPU