For the last month (at least since SU6), I have had this CTD issue occur every time I click the “Ready to Fly” button. I have already submitted a zendesk ticket that has not helped solve the issue. I am running the steam version of MSFS. My system specs are as follows: Windows 10 21H1 32 GB RAM …

Followed your advice and it appears that the CTD was caused by the keybindings on my Honeycomb Bravo. I reset them to default and the CTD is gone. Now I get to go through the process of creating new ones.

Microsoft Flight Simulator Forums

Imediate CTD when Clicking the "Ready to Fly" Button with No Error

Bug Reporting Hub Crashes (CTDs)