Update
-Reverted GPU game settings to default in Adrenalin
-Limited framerate to 60 (monitor 240Hz capable)
-On advice of GC provider, removed current video driver with AMD utility (safe mode) and reverted to 24.9.1, changed game settings to default in Adrenalin
-Repeated process and upgraded to beta 24.20.11.1 driver
-Dropped corecount to 30 in MSconfig (as per this steam thread - Workaround: CTD at 87% - Loading world - Multicore Problem AMD Threadripper - #47 by OnAnyMouse2758)
-Further dropped core count to 20
-Uninstalled game completely and reinstalled
-Physically cleaned inside PC, verified 2 different rails for power connectors (no significant dust buildup)
-Reverted to 24.10.1 driver, default settings
The only thing I have not done so far is reseat my RAM and/or remove one or more sticks. RAM slots are blocked by CPU heatsink, so this would required re-seat of the heatsink and I currently have no thermal compound for that.
About to run furmark and memtest86 to check for errors