As it’s NVMe that should be fine flying and MSFS should load more quickly than you’re used to but I would suggest any other running programs or offscreen data be kept off that drive to keep freezes and pop-ins at bay, but of course these would be more noticeable on normal SSDs. The same advice for virtual memory and the rolling cache, keep them away from your packages as you don’t want scenery being accessed while other stuff is loading in from the same drive.