After ~20h of gameplay in career mode I face a very similar issue:
Reproducable after choosing an VIP fly (LFAY to EGHI with an own Cirrus Vision Jet) the problem will occur during the start up provedure. Sometimes eben while holding short before entering the runway. Now, the error even occurs in different jobs… so now it’s unplayable 
Specs
GPU: 4090
CPU: AMD 7950X3D
RAM: 64 GB
Win 11