FlashgodVR:
On my end i have a workaround and i think i know what the problem is. The mouse cursor isn’t confined to the game window, as soon as it gets outside of it and you click, the game window gets out of focus, making all the interactable areas and objects inactive.
I just made a report here outside of the VR topic. So far it seems random to me when then mouse can escape. I saw it sticking until I ended a flight and then it was unbounded.
Mouse Can Leave Primary Monitor - Bug Reporting Hub / Hardware & Peripherals - Microsoft Flight Simulator Forums