I’m finding this too, although I haven’t experimented with different aircraft to see if it affects all of them.
On the JF Turbo Arrow (my go-to aircraft), the control hotspots are displaced to the right by about 10mm. If you can find the sweet spot, you can actuate the control, but it is a complete PITA.
My main 28" monitor is running in 4k 3840 x 2160 with the side screens (21" monitors) both 1920 x 1080; I wonder if that has anything to do with it?