Something to consider:
If you have a PC with an built in or internal videocard/output separate from your Main GPU use that output to the monitor you use for popouts or other related SIM apps. This frees up your Main GPU and can eliminate any reduction in performance for the Sim due to those popout windows and such.
Just a thought. I used to have an internal video output capable PC but forgot to make sure I got one with my new PC so kind of miss that ability.