Playing with priorities is a recipe for gremlins to appear at some stage. It’s better to just assign cores (Affinity) to games, browser(s) and ‘normal’ apps. For any system related processes leave them as they are, just tinker with the ‘main’ apps you are using on your desktop, literally.
I found the ‘Probalance’ and ‘Smartrim’ features to cause performance issues so I only use Lasso for its persistent affinity-allocating powers, and that’s it.