MSFS crashes when 2nd GPU is used

What you’re doing should work and it should work in DX12. I have a similar configuration and I have no issues. As @Portalearth420 mentioned, it’s quite likely to be a driver problem. I would roll back (or forward) to a known good driver version (I’m still on 531.29, and it works fine for me).

There should be no need to go to DX11, but no harm in trying it if you’re not using sim pop-outs (G1000 etc), but if you are, that will affect your performance.