Multimonitor setup causes Mouse to stop interacting with aircraft in certain circumstances

Do you have the same issue if you follow the OP’s steps to reproduce it?

CONFIRMED - it has always been like this.

Also, even on a Single Monitor, if an Instrument Display is popped out, then interacting with that popped out windows, with the mouse , to MOVE the window, also freezes the SIM, while Drag Focus is on that window.

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CONFIRMED