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Empty the Community Folder (if you don’t know how to do that, search here on the forum for how to locate that folder on your hard drive and then simply rename the folder if you want to keep the mods you may have downloaded which for some users can cause CTDs if the mods were not updated for recent Sim Updates)
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Update Windows 10 OS
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Update your GPU driver (google that if you aren’t sure how or you can post here)
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Don’t have anything else running in the background if you can avoid it (so things like Discord, MSI Afterburner, even non-Windows virus protection apps…Microsoft Flight Sim Support website has a long list of apps they think can cause CTDs and recommend you turn them off before you file a Bug report with them on CTDs)
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No overclocks on CPU or GPU
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Hard drive is formatted NTFS and not exFAT (likely not a problem for your system)
Check the MSFS Support page as they have a few articles I think that give suggestions of things to check before filing a Zendesk support ticket. The items above that I listed are common things everyone here looks for as some users have found these things cause CTDs for their system, but it’s really hard to diagnose and can come and go (I never had them until after SU5 and then they started like you right at start up…for me I had to update my C++ drivers but I stumbled across that fix and it’s worked so far for the last few months). Good luck.