I have a B450 AMD based m/b too and updated the chipset drivers last week (ver. 4.11.15.342) , I’ve not tried anything other than MSFS but it doesn’t seem to be causing me any issues with that.
I did have a problem with a previous AMD chipset driver though, but that was solved by disabling my anti-virus before reinstalling it. Since then I have always disabled the AV before installing the chipset drivers.
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