I’ve had no problems going in and out of VR using the Pico 4 and Virtual Desktop plus the Toolkit, but as I’m on the latest Beta in MSFS I have also noticed recently that that I sometimes get a pause and the Steam VR waiting dialogue box, it resolves itself after a few seconds though. I use a button on my Thrustmaster Airbus joystick to switch between 2D and VR and a second button to recenter the view in VR.