I’ve just come on to post a similar thing. Set up Pica 4 today for first time. Set up Streaming Assistant (wanting to try that before buying Virtual Desktop) and Steam VR. Steam VR working fine in the headset - can go through tutorials etc. just fine. Can view my desktop and launch MSFS fine and start a flight in 2D mode. As soon as I hit CTRL+Tab, MSFS freezes - sound still playing but otherwise unresponsive. I need to get to Task Manager to kill MSFS. Tried a few times, restarted PC etc.
No joy. Any ideas? One thing I do note, when I try this I’m getting a lot of coil whine from my GPU which remains after MSFS has been killed. The coil whine stops once I end Steam VR so I suspect Steam VR is the issue but wanted to ask if anyone had any ideas?