Yes, but:
- you need a Wifi connection from PC to PICO4 that at least can transfer 800mbit/sec
- you need the virtual desktop app on the PICO4 (see pico store, about 20$) and the client software on the pc (free)
- you need openXR
As in my above linked post ypu can see it works very well with MSFS …
Oh and of course you need really strong hardware…